As a result, you may not make as much EPO as usual. VenAccess is a trademark of Vifor (International) Inc. Switzerland. It's a more immediate treatment than supplements or dietary changes. In the first group, some people continued taking iron by mouth, while other people took Injectafer. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre taking Injectafer. Dizziness. HRT, like other medications, does have some side effects and these are thought to be quite common. Brand-name medications usually cost more than generics. Health careproviderscan provide information on how longside effectslast by checking amedication guide. (One treatment course includes two doses of the drug.) Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. However, side effects at the 150 mg dose may indicate that you might not . They can recommend appropriate treatment options. Feraheme is also approved to treat IDA in adults who either didnt have improvement in their IDA or had side effects with iron treatment thats taken by mouth. Your body then uses the iron from Injectafer to make hemoglobin and new RBCs. Ask your doctor or healthcare provider if Venofer is the right choice for you. Call your doctor for medical advice about side effects. signs of inflammation in the lining of your stomach --pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, fever. 1xo`[kg'#KS#.#`uv:PM1+Ob`>y/8:6Ghl:y9B+-,9m[ Understanding what thoseside effectsare can lead to a strategy to prevent them. Injectafer is available only as a brand-name medication. A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Diarrhea. Terminal half-life ranges from 7 to 12 hours. Its important to note that youll get Injectafer doses from a doctor or healthcare professional in a medical facility. Sharing this information can help you avoid potential interactions. This is only a brief summary of general information about this medicine. Before using, check this product visually for particles or discoloration. Other drugs may interact with iron sucrose, including prescription and over-the-counter medicines, vitamins, and herbal products. The dosing for iron replacement treatment in pediatric patients less than 2 years old with Peritoneal or Hemodialysis-Dependent CKD or Non-Dialysis-Dependent CKD have not been established. Drug interactions may change how your medications work or increase your risk for serious side effects. This could happen because Injectafer helps increase their hemoglobin levels, but it doesnt address the underlying cause of their anemia. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Hes an expert in genetic testing, genetic analysis, andprecision medicine. Precautions. Only 10 mg may be excreted by the body the next time it goes through the liver, and possibly only 5 mg the nextpass. Once you have waited for 30 minutes after the injection, you may go home, providing you are feeling well. Venofer is for use in adults and children at least 2 years old. Always review your medical history with the treatingphysician. Brandon ColbyMD, a medical expert specializing in preventive medicine and clinicalgenomics. Headache. For instance, there are some experts who believe there are long-lastingside effectsfromCOVIDthat were not aware of just yet. And this can affect how well those parts of your body are able to work. Some drugs may have another patient information leaflet. Follow all instructions closely. 5 0 obj You are encouraged to report side effects to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. The rest of the people switched from taking iron by mouth to taking an iron product other than Injectafer thats given by IV. Spacing your Injectafer doses out at least 7 days helps to reduce your risk of side effects. <> Call your doctor right away if youre having a severe allergic reaction to Injectafer, even if youve had doses of the drug in the past without any problems. If youre taking iron pills, be sure to tell your doctor before starting Injectafer. Grapefruitjuice may be healthy for people to drink, but it can cause someseriousside effects. People in the study received treatment with either Injectafer or Venofer. Here are answers to some frequently asked questions about Injectafer. Back pain. Other drugs are available that can treat iron deficiency anemia (IDA). Both Injectafer and Feraheme belong to a class of medications known as iron replacement products. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. endobj This is why family members often have the same issues with drugs as others in theirfamily. How long does iron infusion stay in your system? Side effects like nausea and low blood pressure are common with most iron infusions. Pain, swelling, or redness at the injection site may occur. This medication is given by injection into a vein as directed by your doctor. Keep all regular medical and laboratory appointments. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Feraheme, or with both drugs (when taken individually). Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Notify your healthcare provider of any irritation at the injection site. Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. So theres no recommended pediatric dosage for Injectafer. Your doctor will determine the best dosage to fit your needs. This is not a complete list of side effects and others may occur. You should always consult your doctor or another healthcare professional before taking any medication. intense abdominal pain. The body cannot metabolize such a high dose fast enough, so it ends up affecting a part of the body it wasnt intended to, such as the stomach. There are 2 tests that your doctor will likely It may also cause nervousness, restlessness, and difficulty sleeping in some people. I can't take oral supplements because they cause horrible debilitating Constipation. Source: Wolters Kluwer Health. 3 0 obj Mild side effects of Injectafer can include:*. Consult your pharmacist or local waste disposal company. If you have any questions about Venofer, please talk with your doctor, nurse, pharmacist, or other health care provider. However, some people may have weight changes as they have improvement in their anemia, which Injectafer is used to treat. Venofer Side Effects. You may report side effects to FDA at 1-800-FDA-1088. If you need to store Venofer at home, talk with your doctor, nurse, or pharmacist about how to store it. However, there has been a report of delayed allergic reaction in someone receiving a second dose of Injectafer. The drug helps increase your hemoglobin level back to a value thats within the normal range. Venofer (iron sucrose) is given as an injection into the veins (intravenously or IV) by a trained healthcare provider. Without enough hemoglobin, the right amount of oxygen may not reach certain parts of your body. Use Venofer as ordered by your doctor. Injectafer contains the active drug ferric carboxymaltose. The Injectafer dosage your doctor prescribes will depend on your body weight. Nausea. Weight changes may be due to symptoms of anemia improving. But its only approved for use in people with CKD who may or may not need dialysis. reese0809 1 yr. ago. Their medical staff can help you set up another time to receive your Injectafer dose. (Hemoglobin is a protein thats found inside your red blood cells.). And this would give you a total cumulative Injectafer dose of 1,440 mg. Injectafer should be given in two doses. These are not all the side effects that may occur; contact your healthcare provider if you have questions. The time it takes to infuse Venofer (iron sucrose) depends on your age, if you're on dialysis, and the type of dialysis you need. If youre concerned about weight changes while youre taking Injectafer, talk with your doctor. Common MRI side effects include dizziness, anxiety, headache, nausea, hearing loud noises, and feeling chilled or hot in the MRI scanner. Injectafer begins working as soon as it enters your body. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Throw away unused or expired drugs. As with all medications, the cost of Injectafer can vary. Iron infusion side effects vary depending on which form is being used. Call your doctor right away if you have chest pain, cough or the need to cough, dizziness, passing out, shortness of breath, sweating, or throat tightness. Once inside your body, ferric carboxymaltose releases iron into your system. Dizziness. Injectafer is approved for use in adults who either: Injectafer contains the active drug ingredient ferric carboxymaltose. However, Injectafer has been studied for use in children with iron deficiency anemia (IDA). The factors influencing how longside effectslast may not provide the answer most are looking for, but it does explain why some people cant take certain medications because theside effectsareunbearable. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. If you have diarrhea while youre taking Injectafer, call your doctor. This gives a total cumulative dose of 1,500 mg of Injectafer. Instead, youll start by receiving just one treatment course of Injectafer. To learn about other mild side effects, talk with your doctor or pharmacist, or see Injectafers package insert. Injectafer is approved to treat iron deficiency anemia (IDA) in certain adults with the condition. During pregnancy, this medication should be used only when clearly needed. Those going through thismedical conditionshould speak to theircare teamfor support andguidance. But some people have a delayed allergic reaction to certain drugs. For example: Say you weigh 105 pounds (about 48 kilograms). Its not known if Injectafer is safe to take during pregnancy. We comply with the HONcode standard for trustworthy health information. With IDA, you have low hemoglobin levels. Tell your doctor if you are taking iron supplements or other iron-based oral medications. This is not a complete list of possible side effects. This way, if you have an allergic reaction to Injectafer, your healthcare professional can treat your reaction. Talk with your doctor. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. If you are breastfeeding, tell your doctor if you notice diarrhea or constipation in the nursing baby. Injectafer can cause low blood levels of phosphorus, which is a condition called hypophosphatemia. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. This website is intended for use by US healthcare professionals only. What should I know regarding pregnancy, nursing and administering Venofer Vial to children or the elderly. Tell your doctor if you are pregnant or plan to become pregnant. Details. Very bad and sometimes deadly allergic side effects have rarely happened. Pain in your limbs. If you do breastfeed while youre taking Injectafer, the drugs manufacturer recommends that you monitor your child for side effects of the drug. Although a single administration of FCM frequently causes transient hypophosphatemia, a 2016 study showed that repeated treatment with FCM is associated with a high risk of developing severe and prolonged hypophosphatemia and should therefore be monitored. Potential injection site discoloration has happened. Potentialside effectsthat are usually mild may include, but are not limitedto: Theseside effectsmay not impact life too much and may only be temporary. I had Venofer infusions, 2 rounds now in the span of three years. In the US - Call your doctor for medical advice about side effects. So the goal of anemia treatment is to increase your hemoglobin level back to a value thats within a normal range. If youre interested in finding an alternative to Injectafer, talk with your doctor. How is Venofer (iron sucrose) given? He said sometimes the reaction does show up after a few doses and unfortunately it takes longer to get over it. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. Evenbirth controlcan lead to severeside effectslike bloodclots. This site is intended for use only by US patients. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. What is the latest research on the form of cancer Jimmy Carter has? This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Iron sucrose can also be mixed in a. ByDr. As described just above in the Allergic reaction section, some people may have an allergic reaction after getting a dose of Injectafer. But you dont necessarily need to eat these foods unless your doctor tells you to do so. Data on file, American Regent, Inc. 1. With this condition, you also have a low hemoglobin level. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. But you kidneys need iron in order to make EPO. Notify your healthcare provider of all medical conditions and any medications, including supplements you are taking. Injectafer isnt a medication that youll take regularly on a schedule. People with IDA have low blood levels of hemoglobin. Venofer 100 mg iron/5 mL intravenous solution, Venofer 50 mg iron/2.5 mL intravenous solution, Venofer 200 mg iron/10 mL intravenous solution, Select a condition to view a list of medication options. This may lead to the person needing a higher dose compared to someone who is muchsmaller. Talk with the doctor. This means you would get two Injectafer doses of 720 mg each. With slow IV injection, the drug is given as a single, slow injection into your vein. Details. <> Injectafer contains the active drug ferric carboxymaltose, while Feraheme contains the active drug ferumoxytol. }|54U|O~?|_v;f\o^(W+/-|^)O65_)rd sm }[x[)y.z Wz?9_jV0ub,`g`s?oXOSp/Kgw$b!Vb$;IvBVR9n|\0ln=;/=,mgw@do,[";/8nJL{n}Bb-|^6[~>a_1H'^M:^vv=iM+x|+Y With slow IV injection, the drug is given as a single, slow injection into your vein. Iron sucrose can harm an unborn baby if you have a severe reaction to this medicine during your second or third trimester. However, not treating iron deficiency anemia during pregnancy may cause complications such as premature birth or low birth weight. Heart failure: Could a low sodium diet sometimes do more harm than good? Blood tests may be needed to check for unwanted effects. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Severeside effectsmay end up causing a lot of disruption in a persons life. Effectiveness of Injectafer compared with iron thats taken by mouth. Upset stomach or throwing up. Get emergency medical help if you have signs of an allergic reaction to Venofer: hives, rash, itching; feeling light-headed; difficulty breathing; swelling of your face, lips, tongue, or throat. Low iron saturation, or iron deficiency, has various possible causes. So we cant say for sure whether the drug is safe to use while youre pregnant. (A generic drug is an exact copy of the active drug in a brand-name medication.). Depending on your doctors instructions and On the other hand, some people may have a poor appetite that goes away when their anemia is treated. This medicine may cause serious types . Injectafer contains the active drug ferric carboxymaltose. If you have questions about the safety of breastfeeding while youre taking Injectafer, talk with your doctor. Learn about uses, cost, how it works, and more. Venofer may cause significant hypotension (decreased blood pressure). endobj Venofer (iron sucrose) is given by injection into a vein as directed by your doctor. Do not start, stop, or change the dose of any drug without checking with your doctor. Click below for effective ways to alleviate the discomfort felt fromside effects and learn how to get a free Medication and Drug Reaction DNAReport. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). Joint pain. In the study, peoples hemoglobin level was measured to check for improvement in their anemia. But they wont receive a total cumulative dose of more than 1,500 mg of Injectafer. xmq92\Kz!yIP}2~(?c/JUCK2~o_N=>K$o/_7'Z+nRkKM^y{u|ZFh$v}]O~vfo=.GowGFodVj-[-~x]Kg~9H'%h={OX/#S|Mc~|]_2nv`wwotn/+$G[{hGrP}sbZG-RGf#l~~l|Qnccml_iPy]G\17c,yPF[28z&I'+B(?rrvi,G?}/;'?;pm>?.i42ONmk~ai_u0z9o_? Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. *Patients are calculated based on an estimated annual cumulative dose. Do not exceed 1,500 mg of iron per dosing course. This information is not specific medical advice and does not replace information you receive from the healthcare provider. For more information and to find out if youre eligible for support, call 877-4-IV-IRON (877-448-4766) or visit the program website. You should not receive Venofer if you have known allergies to iron sucrose. XAO$$d|0tX1`Q$Il#FBm}{#h!/;[bOvvg7 ?tMl7/+wya^,~PA}6&Ftb19OeJ6-a3acKjcpkeGq+7/nO AJJ:Okyfp;xw|]McmK?9"t0m%. Hypophosphatemia risk appears to be substantially lower with other IV iron formulations. And this person had gotten their first dose of the drug without having an allergic reaction. IQVIA [NSP Audit from MAT November 2013 to November 2018]. Boxed warnings alert doctors and patients about drug effects that may be dangerous. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Injectafer and Venofer are both brand-name drugs. taste impairment. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. dizziness. In clinical trials, serious allergic reactions occurred in 0.1% to 1.5% of people taking Injectafer. Allergic reactions are most likely to occur within 30 minutes of receiving Venofer. However, some people can experienceside effectsfor much longer - days, months, or indefinitely. Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Others last much longer (even a lifetime), which can be quite traumatizing to people. Discuss the risks and benefits with your doctor. Iron-refractory iron deficiency anemia (IRIDA) is a genetic form of anemia. The information provided is not intended to replace your healthcare provider's medical advice. Available for Android and iOS devices. Also, keep in mind that if your anemia is causing certain symptoms, treatment with Injectafer may help those symptoms go away. This information should not be used to decide whether or not to take Venofer or any other medicine. Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in adult and pediatric (2 years of age and older) patients with chronic kidney disease (CKD), and is administered only by or under the supervision of your healthcare provider. Examples of these side effects include dizziness and nausea. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. And this could lead to weight gain, if they increase their food intake. Check with your pharmacist. If you have questions about the blood tests youll need to have done to monitor your anemia, talk with your doctor. They can recommend if this is safe for you to do. If you have questions about the best diet for you during Injectafer treatment, talk with your doctor. In clinical studies, diarrhea was reported in less than 1% of people taking Injectafer. But so far I feel better than before the infusion. The researchers found that compared with their hemoglobin level before the study: But the actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. In some cases, they may even recommend that you use a drug other than Injectafer to treat your anemia. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The Role of Genetics in Multifactorial Disorders, The Power of DNA Testing and Predictive Medicine, A Guide to Genome Explorer (Free Version), Whole Genome Sequencing in As Little As Three Weeks, What Diseases Can Be Detected Through Genetic Testing, Breast Cancer Genetic Testing: Pros and Cons, At Home Genetic Testing for Breast Cancer, DNA Tests for Breast Cancer Genetic Testing, What to Do When Medicines Have Side Effects, Blood Type and COVID: Infection Risk and Severity, Where Can I Get My Blood Type Checked for Free, How to Find Biological Father Through DNA. Cardiovascular health: Insomnia linked to greater risk of heart attack. This allows them to manage any side effects that you may have following your dose. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. You may need extra iron because of blood loss during kidney dialysis. Its not currently available in generic form. Selected from data included with permission and copyrighted by First Databank, Inc. What to Expect When You Get Your Whole Genome Sequenced, DNA Data Can Help You Understand Ehlers-Danlos Syndrome (EDS). Together, they can recommend ways to help you manage a body weight thats healthy for you. Together, you and your doctor can discuss the benefits and risks of treatment options for anemia. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. This is not a list of all drugs or health problems that interact with this medicine. To make sure Venofer injection is safe for you, tell your doctor if you have: hemochromatosis or iron overload (the buildup of excess iron). Below are examples of these side effects. This document does not contain all possible drug interactions. Low blood pressure. No, Injectafer itself wont make you gain weight. The infusion concentration should not be less than 2 mg of Injectafer per mL of solution. The insurance company will review the prior authorization request and decide if the drug will be covered. For this purpose, Injectafer is approved for use in adults who either: Venofer is also approved to treat IDA. Cancer patients who have anemia and are taking an ESA. Find comprehensive medical information for Venofer intravenous on RxList including its uses, side effects, precautions, drug interactions, overdose, pill images & warnings . Venofer (iron sucrose injection, USP) Rx Only DESCRIPTION Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. WARNINGS/CAUTIONS: Serious hypersensitivity reactions, including anaphylactic-type reactions (itching, hives, swelling, wheezing, difficulty breathing, fainting and/or other allergy symptoms), some of which have been life threatening and fatal, have happened in patients receiving Venofer. This is why they have a programcalledMedWatchthat encourages Americans to report adversereactions. Knowing how longside effectslast can help with the decision on whether to use a particulardrug. Or your doctor may recommend that you change your eating habits to include more iron in your diet. So you wont pick up this medication from a pharmacy. Depending on your anemia symptoms, your weight changes may be different than those described here. After receiving IV iron therapy, you will be monitored for 30 minutes to make sure you do not have an allergic reaction or a drop in blood pressure. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Serious side effects should be reported to a physician and/or PharmD for medical advice. If you have more questions about how Injectafer will affect your anemia, talk with your doctor. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction. In this group, after 35 days of treatment: In clinical studies, Injectafer was effective in treating IDA in adults with CKD who didnt require dialysis. You should not be treated with this medicine if you have ever had an allergic reaction to an iron injection. But if they become more severe or dont go away, talk with your doctor or pharmacist. These pregnancy-related problems include preterm delivery and low birth weight of your infant. I got Venofer twice in the last few years and now my iron deficiency is worse than ever, first time my hemoglobin is down to 11,2. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. Iron is important for many functions in the body, especially for the transport of oxygen in the blood. Phosphorus also helps your nerves function properly. Do not use Injectafer in people with a history of hypersensitivity reactions to Injectafer or any components of the drug product. People who weigh less than 110 lb (about 50 kg) will receive two separate Injectafer doses of 15 mg/kg of body weight. But its not known whether this poses any risk to a child whos breastfed. Vomiting. These symptoms can include: While youre taking Injectafer, your doctor will monitor your phosphorus levels if youre at risk for hypophosphatemia. Venofer pregnancy and breastfeeding warnings. This test measures the amount of hemoglobin in your blood. If you have any of these health problems: Too much iron in your body or anemia from a cause other than low iron. Generics tend to cost less than brand-name drugs. If you have questions about drinking alcohol while youre taking Injectafer, talk with your doctor. A variety of tests can diagnose iron deficiency anemia.